chlorambucil for cats ibd

The goal of treatment is to decrease and ideally resolve the symptoms of the. Hematological monitoring is warranted every 34 weeks to assess for neutropenia.

Hunter S Story Animal Medical Center Of Seattle

Chlorambucil is an alkylating antineoplastic agent that is routinely used in cats with lymphoplasmacytic IBD as well as those with small cell lymphoma.

. Hello I have a 13 year old male kitty that was recently diagnosed through biopsy with small intestine IBD. He is currently on prednisolone once daily and has. Because of client preference two cats were switched to 20 mgm 2 chlorambucil orally once.

It is an immune system suppressing drug given to dogs or cats for immune-mediated disorders such as cancer including leukemia and. Response to therapy for small cell lymphoma is approximately 7590 with most cats alive longer than 2 years when they are treated with a combination of prednisolone and. Chlorambucil is suppressive to the immune system and should be used with caution in patients already immune suppressed such as FIV cats or with chronic infections.

The exact pathogenesis is thought to be multifactorial. Inflammatory bowel disease IBD is a common cause of chronic gastrointestinal signs in cats. Hematologic parameters should be monitored regularly if chlorambucil is used.

It is an antineoplastic and. Treatment with chlorambucil is considered the standard for cats with small cell lymphoma. In cats chlorambucil with prednisolone is used if the response to glucocorticoid treatment is inadequate.

Chlorambucil is used in cats to treat lymphocytic leukemia lymphocytic plasmacytic enteritis Pemphigus inflammatory bowel disease and feline eosinophillic. Leukeran is the brand name for generic chlorambucil. Chlorambucil is generally used in conjunction with corticosteroids in cats with severe inflammatory bowel disease or those with low-grade small cell intestinal lymphoma.

Chlorambucil better known as Leukeran is a nitrogen mustard derivative that belongs to a group of chemicals known as alkylating agents. All cats initially received chlorambucil at a dosage of 20 mgm 2 orally once every 2 weeks. The alkylating agent chlorambucil is beneficial for managing refractory cases of IBD particularly in cats.

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